Evaluation of micronucleus frequency by acridine orange fluorescent staining in bucccal epithelial cells of oral submucosus fibrosis (OSMF) patients

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Re: The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate. (Mutagenesis, 20, 411-415, 2005).

The authors thank Dr Raymond J. Proudlock for his comments on their article. First, studies on the genotoxicity of lead salt are inconclusive. Pelclova et al. (1) did not detect a significant increase in structural aberrations (chromosome and chromatid exchanges, and breaks) in 22 workers from a lead battery plant. In contrast, Vaglenov et al. (2) found a significant increase in MN frequency am...

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Determination of micronucleus frequency by acridine orange fluorescent staining in peripheral blood reticulocytes of mice treated topically with different lubricant oils and cyclophosphamide.

To ascertain whether used and re-refined lubricant oil absorbed through the skin can produce a genotoxic effect or cytotoxicity in mouse bone marrow cells, we examined the induction of micronucleated erythrocytes of peripheral blood after cutaneous application. Both re-refined and used lubricant oils showed a weak but significant induction of micronucleated polychromatic erythrocytes compared w...

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evaluation of genotoxicity in patients subjected to panoramic radiography by micronucleus assay on epithelial cells of the oral mucosa.

radiography is one of the most valuable diagnostic tools used in comprehensive dental care. although there is no safe level of radiation exposure, the possible risk associated with exposure to radiation, must be elucidated. to date, a variety of assays have been proposed to assess the mutagenic potential of genotoxicants; however, these methods are typically laborious and time consuming. the ai...

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ژورنال

عنوان ژورنال: Egyptian Journal of Medical Human Genetics

سال: 2013

ISSN: 1110-8630

DOI: 10.1016/j.ejmhg.2012.11.004